Cone snail venoms are true pharmacological treasures, typically containing hundreds to thousands of natural bioactive compounds, also called conopeptides. The therapeutic potential of these cone snail peptides is attracting a lot of interest.
As a proof of concept, Prialt® or Ziconotide, the first marine FDA-approved drug, is an omega-conopeptide isolated from the venom of Conus magus.
This new drug selectively targets N-type calcium channel, and its analgesic effect is 1000 times more powerful than morphine.
At least 10 other conopeptides purified from cone snail venoms have entered preclinical and human clinical trials to treat pain, ischemic stroke, epileptic seizure or myocardial infarction.
Each of the 700 recorded Conus species produces a unique and highly complex mixture of peptide-rich natural compounds.
With less than 1% of the cone snail venom biodiversity pharmacologically characterised, there is a tremendous potential for discoveries.
BioConus stems from more than 10 years of experience in venom research.
We use our unique knowledge to extract pure venoms from live cone snails in a sustainable and ethical way.
Venoms are natural libraries of thousands of natural substances.
Milked venoms from snakes, spiders, scorpions and even hymenopterans are readily available for life science research and compound screening.
Up to now, venoms from cone snails were access limited and always obtained from dissected animals, a method that is not sustainable, and at best, ethically questionable.
Thankfully a milking method allows pure venom to be collected from live cone snails.
In addition, milked Conus venom has many advantageous properties over dissected venom:
|Dissected Venoms||Milked Venoms|
|May include cellular debris and unprocessed molecules that unnecessarily complicate the purification of the active conopeptide.|
Free of contaminations, cellular debris and containing none or traces of the unprocessed toxins and degradation products.
Individuals within one Conus species are well known to produce different venom profiles. Indeed,
Cone snail venoms are collected and pooled in batch to minimise individual variations.
High content of unsoluble material.
Sacrificing of hundreds of cone snails to purify and characterise one single peptide.
|Sustainable and ethically acceptable|