BioConus

Cone Snail Venoms: a New World of Pharmacological Treasures

High-quality venoms extracted
from live marine cone snails

 


Cone
snail venoms are true pharmacological treasures, typically containing hundreds to thousands of natural bioactive compounds, also called conopeptides. The therapeutic potential of these cone snail peptides is attracting a lot of interest.


 

 As a proof of concept, Prialt® or Ziconotide, the first marine FDA-approved drug, is an omega-conopeptide isolated from the venom of Conus magus.

This new drug selectively targets N-type calcium channel, and its analgesic effect is 1000 times more powerful than morphine.

 

At least 10 other conopeptides purified from cone snail venoms have entered preclinical and human clinical trials to treat pain, ischemic stroke, epileptic seizure or myocardial infarction.

 

Each of the 700 recorded Conus species produces a unique and highly complex mixture of peptide-rich natural compounds.

 

With less than 1% of the cone snail venom biodiversity pharmacologically characterised, there is a tremendous potential for discoveries.

BioConus stems from more than 10 years of experience in venom research. 

We use our unique knowledge to extract pure venoms from live cone snails in a sustainable and ethical way. 

 

Properties of Cone Snail Milked Venom

Venoms are natural libraries of thousands of natural substances.
Milked venoms from snakes, spiders, scorpions and even hymenopterans are readily available for life science research and compound screening.
Up to now, venoms from cone snails were access limited and
always obtained from dissected animals, a method that is not sustainable, and at best, ethically questionable.
Thankfully a milking method allows pure venom to be collected from live cone snails.

In addition, milked Conus venom has many advantageous properties over dissected venom:

  Dissected Venoms  Milked Venoms
May include cellular debris and unprocessed molecules that unnecessarily complicate the purification of the active conopeptide.

99.9% pure

 Free of contaminations, cellular debris and containing none or traces of the unprocessed toxins and degradation products.

Individuals within one Conus species are well known to produce different venom profiles. Indeed,
a particular molecule of interest may be
produced by a unique cone snail, and
therefore, when more material is needed for
the complete characterisation of a hit, it is impossible to get this additional material since
the Conus mollusc has been sacrificed.

Highly homogeneous

 Cone snail venoms are collected and pooled in batch to minimise individual variations.

 
High content of unsoluble material.

  Higher solubility

Sacrificing of hundreds of cone snails to purify and characterise one single peptide.

  Sustainable and ethically acceptable

 

News and Events

Two New Publications using our venoms in 2015!

  1. Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom. J Proteomics. 2015.
  2. Hormone-like peptides in the venoms of marine cone snails. Gen Comp Endocrinol. 2015.


BioConus is now on Linkedin, follow us!

Contact us for any enquiry or a quote!
info@bioconus.com


Testimonials

"Communication was excellent. [...] I was really happy to receive the answers to some of the specific questions about the sample that I had asked."

"Transaction was also excellent."

"I would certainly mention Bioconus."
S.R.
, Monash University, Melbourne, Australia